A stylised illustration of a human brain filled with a multicoloured heatmap pattern and overlaid with small black directional arrows, representing data or neural activity.

We need a much stronger interaction between Neuroscience, Machine Learning and Mathematics!

Brain science is sometimes considered to be the final frontier of human knowledge. In recent times it has become abundantly clear that we need a much stronger interaction between Neuroscience, Machine Learning and Mathematics.

On one hand, there is a general agreement that brain science can inspire better machine learning (ML) algorithms, and on the other hand, we think that modern machine learning can also help unravel the secrets of brain function by suggesting better experiments and data analysis methods. Finally, mathematics can not only provide the common language to ML and brain science but also give the much-needed analysis tools to understand information processing in both artificial and biological networks. 

Therefore, two neuroscientists Arvind Kumar from EECS, KTH and Srikanth Ramaswamy from Newcastle University and an AI expert Saikat Chatterjee from EECS, KTH joined hands to organize a meeting for the mathematicians, neuroscientists and machine learning experts. This three-day meeting aptly named the MAIN meeting (Mathematics, Artificial Intelligence and Neuroscience) was held at the Digital Futures hub from 13-15 December 2021.

The meeting was organized in a hybrid way given the Covid-19 situation. The Digital Futures space with all its infrastructure proved to be an excellent venue for the hybrid mode conferences. The talks were divided into seven sessions which were separated by panel discussions and coffee breaks. 

– We started the first day with three tutorials to bring the mixed audience up to speed. This was followed by talks on the use of topological tools to study complex high dimensional objects including biological neurons and neural networks. The final session was devoted to the understanding of network activity dynamics and neural coding using tools from topology and information processing, explains Arvind Kumar. 

The second day started with talks on the use of machine learning tools for neuroscience, in particular, the analysis of EEG data to decode brain state and automatic detection of animal behaviour. The remaining talks focused on opening the black box of deep learning – a special and powerful class of machine learning and getting some insights into what makes it so powerful in certain application domains. Then followed presentations and panel discussions on powerful interpolation schemes from the field of AI, as well as mathematical tools from Clifford Algebra for computer vision.

The third day focused on neuroscience with two talks on how artificial intelligence, AI, can be used to model individual neurons and discover synaptic plasticity rules. Invited speakers also talked about various levels of the brain’s complexity that are yet to be fully characterized and included in computational models. One such aspect of brain science is neuromodulators – chemicals that modify brain circuits continuously in a state-dependent manner. While understanding of neuromodulator action may be limited, early steps that are being taken to include them in modern machine learning were presented.

– Each session generated lots of questions from the audience which were taken up in the panel discussion but the discussions continued at lunches, dinners and are even continuing now over emails. It was really a privilege to host some of our colleagues in person during the pandemic, who made extra efforts to come to Stockholm, says Arvind Kumar.

As the meeting started on 13th December – the Swedish Lucia day, it was fitting that the audience and invited guests were surprised by the KTH staff choir with Christmas songs. 

– This meeting has reinforced our existing connections and formed new interactions which we hope will precipitate long-standing collaborations, says Saikat Chatterjee. We now look forward to building on the success of this edition of the MAIN meeting and establishing it as a regular event of the academic calendar. The meeting was funded in parts by the Swedish Research Council, KTH Digitalization Platform and Digital Futures. We especially thank our colleagues at Digital Futures who helped us with the organization and logistics.

More news

Two presenters stand at the front of a room speaking to an audience. Behind them, a large screen displays an agenda with event details. The room has wood panelling and large windows.

Students and global business leaders convene at Digital Futures to redesign the future of talent

20/05/2026

International students, senior business leaders, and academic representatives gathered Tuesday at KTH Campus for the “Emerging Leaders...

Several small drones hover indoors in a spacious room with large windows, while two people stand in the background, slightly out of focus, engaged in conversation.

Drone Gymnasium explores new relationships between humans and autonomous technology

19/05/2026

A new video released by the Digital Futures research project Drone Gymnasium offers a glimpse into an...

Book cover titled MUSIC & SLEEP: A Scientific Perspective features a stylised outline of a sleeping person with a large musical note and sound waves, edited by Kira Vibe Jespersen and Björn Rasch.

New book release: Music and Sleep – A scientific perspective

12/05/2026

We are pleased to share the publication of Music and Sleep – A Scientific Perspective, edited...

A woman with glasses and a black shirt stands smiling with arms crossed in front of a glass wall displaying the words digital fut. A chalkboard covered in drawings and writing is visible to the left.

Advancing Parkinson’s research: Satarupa Chakrabarti on brain-based diagnostics and her time in Sweden

08/05/2026

Diagnosing Parkinson’s disease has long relied on observable symptoms—despite the disease originating in the brain....